Lipotec introduces a new peptide for reprogramming the skin through epigenetics
Epigenetics is becoming a new big trend in the skin care industry and is expected to open infinite possibilities for the design of new strategies against aging. Related to the interpretation of information, it can be very helpful to understand the regulation of complex processes in the skin. Just as a text in the book can be interpreted differently depending on the reader’s emotions and experience, epigenetics relate to the various possible readings of the information stored in the DNA or genes, contingent on diverse conditions of the environment.
Among the biological processes regulated by means of epigenetics is the control of the fate of progenitor cells located in the basal layer of the epidermis. The epidermis is one of the most active tissues in terms of regeneration thanks to the ability of the stem cells from the basal layer to divide and renew themselves. With age, this regenerative potential and the overall function of epidermis are reduced resulting in the development of aging signs, such as appearance of wrinkles and loss of radiance.
Lipotec’s latest development, REPROAGE™ peptide, may induce cellular reprogramming in the epidermal basal layer through the modulation of epigenetic elements, which can help reactivate basal cells and their regenerative abilities, leading to an improved appearance of mature skin.
Specifically, the microRNA-145 is an epigenetic regulator known to repress the activity of the stem cell transcription factors, restraining the stemness properties of the basal cells. The new peptide reduces the levels of microRNA-145 and increases the level of the stem cell factors related to stemness, contributing to an improvement in the skin properties.
Two in vivo assays, performed using 2% peptide solution twice a day during 56 days, showed a general improvement in skin complexion and more radiance with 1.5% increase in luminance as well as a rejuvenated skin with epidermal self-renewal activity increased to the level of a skin 17 years younger in the 50-55 years old volunteers and up to 41.3% decrease in skin roughness.
REPROAGE™ peptide assists in obtaining a smoother, more radiant and visually rejuvenated complexion and can be incorporated into any anti-aging formulation to cope with the slowdown in skin regeneration that takes place with age or in products designed to rejuvenate the skin.
REPROAGE™ is owned by The Lubrizol Corporation or its affiliates.© 2016 The Lubrizol Corporation. All Rights Reserved.