Skin is a first line of protection for our organism so it is constantly challenged by a large number of microorganisms. It is right but that most of them life in harmlessly without causing clinical disease, thanks to actually the skin’s immune system barriers. The Stratum Corneum (microflora) means a first physical protection against those external aggressions. This first barrier could be beaten. If it happens, automatically a second natural barrier reacts to this intrusion: the innate immune system. This skin’s immune mechanism, with the aim of keeping the natural skin’s balance, produces the Antimicrobial Peptides (AMPs) which contribute to eliminate potential pathogens. This intricate skin’s system could but be weak punctually or permanently by several environmental, biochemicals, physiological… facts. It is why, and so for how important the skin’s protection is to the organism, it is recommended to reinforce this natural mechanism to optimize the results. Bodyfensine reduces the risk of possible infections, such as in acne-prone skin by reinforcing this natural defense system, stimulating the expression of human-B-defensins -2 and -, an AMPs’ subclass-, providing so a chemical barrier to fight against microbial growth.